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Scientific literacy is an important aspect that can be used as a provision for students in facing the era of disruption, so this study aims to describe the development of scientific literacy in elementary schools through the implementation of ecoprenuership program. Case study research is used as a method that is considered relevant in providing an overview of the development of scientific literacy in 22 special students especially focused on 6 students as gatekeepers. The results of this research were supported by data from 2 orthopedists, 5 teachers in the class, a extracurricular teacher, and a headmaster. This research proves that the implementation of ecopreneurship program can be the basis for developing scientific literacy in the school. This can be seen in the learning process which are considered capable to accommodate the needs of each special students, even though in their implementation each student has their own limitations cause treatment and the intervention of each student is different. The diversity of treatment of students produces varied findings on scientific literacy development. The results of this study are expected to be a reference for the school in developing scientific literacy as a preventive effort in the face of disruption era.