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Myoglobin is an intracellular protein which has a vital role in maintaining oxygen hemostasis within living tissue. This protein has the ability to bind and send oxygen to mitochondrial membrane to enable transduction of energy. The liver is the biggest organ in the bodyand has complex functions. Based on the complex functions, liver needs quite a big amount of oxygen, so the metabolism process can be performed well. This study aims to detect mRNA expression in the liver of rats (Rattus novergicus) in normoxia. The study was conducted at the Biochemistry and Molecular Biology Laboratory of the Biology Major of the Faculty of Mathematics and Natural Sciences, UNJ. This study utilized quasi-experiment method. The study results show that myoglobin mRNA is expressed in the liver of rats (Rattus novergicus) in normoxia on 114 pb. This result can create a new paradigm towards myoglobin gene that this gene might be a constitutive gene. This information can be the basis that living tissues have strategies for mechanism of adaptation towards low oxygen environment by increasing the expression of myoglobin in the tissue.