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Background:The incidence rate of acute lymphoblastic leukemia cancer continues to increase every year. Child diagnosed with cancer cause anxiety for parents. Impact of anxiety experienced such as sleep disorder, fatigue, inability to make decisions. Factors that are needed in anxiety are religiosity and social support. Objective: To Analyze the relationship of religiosity and social support with the anxiety of mothers who have children with acute lymphoblastic leukemia Method: This research uses cross sectional design. Sampling was done by purposive sampling technique. The sample is used 30 mothers who had children with acute lymphoblastic leukemia at Ulin General Hospital Banjarmasin. Then analyzed by using Spearman Rank test with significant value p <0,05. Result: The result showed that mothers with high religiosity were 21 people (70%), mothers with high social support of 21 people (70%), and while mothers who have moderate anxiety of 12 people (40%). The Result of analysis test of correlation of religiosity with mothers anxiety with significance level 0,05 got p value= 0,001; r= -0,555. Result of analysis test of relationship of social support with mother anxiety which have child with acute lymphoblastic leukemia got p value = 0,003; r = -0,480. Conclusion: There is a significant correlation between religiosity with mothers anxiety. There is a significant correlation between social support with mothers anxiety. The importance of health workers in improving the religiosity and social support of mothers who care for children with acute lymphoblastic leukemia since their child diagnose acute lymphoblastic leukemia.