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The aim of this research was to evaluate the influence of Mobile - NOS Model of Learning to Students Understanding of Nature of Science (NOS) and Scientific Literacy on general chemistry course. In form quasi experimental, this was carried out by posttest only control group design at the Faculty of Mathematics and Science Education of IKIP Mataram. The research subjects were 75 students participating in the General Chemistry course for the academic year 2018-2019 that taken by the saturated sampling method. Subject separated on two groups that were experiment group was treated by Mobile - NOS Model of Learning and control group with NOS Oriented Learning. Data were collected by understanding NOS questionnaire and scientific literacy test and observation sheet. Data was analyzed by independent samples t test. Research result showed that there are influence of Mobile - NOS Model of Learning to Students Understanding of Nature of Science (NOS) and Scientific Literacy.