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Dyslipidemia is a disease caused by complications of Type 2 Diabetes Mellitus (T2DM). DMT2 is caused one of them by high-fat foods that can increase the production of Reactive Oxygen Species (ROS) so that it can be prevented and treated with foods that contain lots of antioxidants such as black soybean tempeh and purple sweet potato. This study aims to determine the effect of giving a combination of black soybean tempe extract (Glycine max (L.) merril) and purple sweet potato (Ipomoea. Batatas L) on lipid profile levels (total cholesterol and High Density Lipid levels) in serum blood of the Diabetes Melitus model Type 2 (DMT2). Rats were fed a proximate nutrition 20 g per day and drank 10% sucrose in an ad libitum for 8 weeks and then injected with STZ multiple low dose intraperitoneal (IP), to become diabetic. Rat blood serum was collected and tested by the Spectrophotometry method to determine lipid profile levels after 4 weeks of treatment. The levels of lipid profiles found were analyzed using SPSS. The results of the study showed that the combination of black soybean tempeh extract and purple sweet potato with a ratio of 3: 1 (P3) was the optimal combination to reduce blood sugar levels, total cholesterol, a combination of 2: 2 (P4) treatment was effective to increase blood serum HDL levels in mice DMT2 models.