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Background: Health information system users have an influence on the efficiency of a system in providing health services so that it can increase the value of patient safety. We conducted a literature review in knowing how the user acceptancre in using a health information system. Method: Literature review is conducted by looking for articles from 2008 to 2018 using a database from PubMed. Articles are accepted in this study if they examine the influence of user attitudes on the running of health information systems in hospitals and primary services. Sorting articles through abstracts and free full text articles. Results: A total of 148 articles on the influence of user acceptance towards health information systems, 25 articles included inclusion criteria. Various user acceptance assessment models such as the Technology Acceptance Model (TAM), and the Unified Theory of Acceptance and Use of Technology (UTAUT) are used in a number of these articles. Most articles explain that cooperative users can make health information system become efficient, but several environmental and personal factors can influence the system. Conclusion: Making an efficient health information system, a cooperative user attitude and acceptance is needed. The existence of environmental and personal factors is an obstacle in the system, so it needs an effort from the hospital management and primary services to improve the quality of existing resources in order to achieve the main goal of improving patient safety. Future research is needed to examine how the hospital or primary care management can increase existing resources.