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High demanding of tofu as a food type containing high protein-s source in Indonesia is followed by increasing amount of tofu waste produced from this industry, both solid and liquid waste. The high amount of organic material of this wastewater (9,880 mg COD/L) results in its potential to be treated biologically by the combination of the anaerobic-aerobic process. To enhance the process efficiency and better quality of the effluent, in this study, coagulation and flocculation process was added as the finishing process after biological treatment methods. The purposes of this research were to evaluate the more effective method between aerobic process and the combination of anaerobic-aerobic process and to determine the best dose of tamarind seed as the natural coagulant. Doses variant used were 1,000 ppm, 2,000 ppm, 3,000 ppm, and 4,000 ppm. The result showed that the aerobic process had a slightly better performance of COD removal compared to the combination process (anaerobic-aerobic), which was about 89.744%. The finishing process, coagulation and flocculation was focused on lowering turbidity level of the effluent of biological process. 2,000 ppm of tamarind seed gave the best result on decreasing turbidity level for both processes, aerobic process (63.745%) and anaerobic-aerobic process (47.567%).