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Wastewater is commonly reused in agriculture in many agricultural countries such as Indonesia. However, this condition leads to various health and environmental issues. In previous studies, Moringa oleifera seeds provably found to be a strong natural coagulant and disinfectant. Yet, its ability to improve the effluents for the leachate treatment in constructed wetland is still unknown. This study aims to investigate the effect of Moringa oleifera seeds in reducing several effluent parameters of landfill leachate from constructed wetland. There was no prior treatment before discharging landfill leachate into subsurface flow constructed wetlands and flew it into flocculation coagulation process using Moringa oleifera seeds. The parameters studied were organic substances (BOD and COD), heavy metals (Cr and Pb) and coliform to determine the efficiency. Result indicated that using Canna indica in constructed wetland followed by Moringa oleifera seeds as flocculation coagulation had more than 85% removal efficiency in all parameters. Although it showed adequately high in the efficiency, the standard sets for bacteriological substance for effluent parameters are yet fulfilled. Therefore, further researches especially by combining Moringa oleifera seeds with other coagulants are necessarily conducted in order to meet the expected requirements.