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Work activity in the process production in the chemical process industry requires an ergonomic work method because the risk of awkward work postures can cause harm to workers, especially related to musculoskeletal disorders (MSDs). The aims of this study ware to analyze risk factors for musculoskeletal disorders related to the individual, job and psychosocial factors in process production workers division in the chemical process industry. Field observations method were carried out on all work activities in the process production division, and questionnaires were distributed to all process production workers to determine complaints and risk factors related to the individual, job and psychosocial factors to the musculoskeletal disorders. Analysis of work posture was carried out using the RULA method. The results in this study, the score 7 of work posture with RULA, that is indicated need work changes and improvements must be made immediately, by redesigning layout and tools in control room, and training with ergonomic participation method. Based on multivariate analysis, the most dominant risk factors associated with complaints of musculoskeletal disorders were the job demand, work posture, and job stress perception.