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Abstract After the enactment of Government Regulation Number 18 of 2016 concerning Regional Devices there was resistance from a number of parties over changes in the position of Regional Hospitals from Regional Technical Institutions (LTD) to the Technical Implementation Unit of Public Health Office (UPT). This resistance must be immediately given a solution so as not to disturb the public services provided. By using a post positivist approach, this qualitative research seeks to analyze the factors that influence organizational resistance from Robbins theory. Primary data is obtained through in-depth interviews while secondary data comes from literature studies on several publications, reports or news about hospitals and regional hospital. The results of the analysis show that organizational resistance of RSD is influenced by structural inertia, limited focus of change, group inertia, threat to expertise, threat to established power relationship, and threat to established resources allocations.