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Caregiver burden is a multi-dimensional stress consist of physical pressures, psychologist, emotional, social, and financial which related to activities in caring children with special needs. The aim of this study was to identify the burden of parents in caring for children with mental retardation in 2 special need schools in Badung Regency. This was a descriptive study with cross sectional approach. Respondents were 265 parents of students with special needs. Zarit Burden Interview (ZBI) was used for data collection, and analyzed using univariate analysis. Among 265 respondents, 51.7% respondents were female parents. Median age was 47 years old (ranged from 24 to 66 years old). The majority of parents (67.5%) had children with mild mental retardation. Univariate analyses indicated that 80% had a mild to moderate burden, 7.2% had moderate to severe burden, and only 0.4% had severe burden. Maanwhile, and 12.5% indicated no burden. Health practitioners are expected to provide education to the parents to reduce the dependency of children towards their parents and to improve the parents coping mechanism in caring for children with special needs.