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Ultraviolet rays (UV) have various radiation waves, namely: UVA, UVB, UVC, infrared, and visible light with their respective effects on the skin. UVA radiation can penetrate the window glass and can react to chemicals of topical drugs and oral drugs which can cause a reaction called photoallergy and phototoxic reactions. Continuous radiation from UVA and UVB can cause degeneration of connective tissues in the skin such as sun-aging (photoaging), skin cancer (photocarcinogenesis), and immunosuppression on transplantation. Based on data from the Meteorology, Climatology and Geophysics Center, Buleleng Regency is one of the districts in Bali which has a high level of sun exposure intensity as compared with other districts. The purpose of this study were to determine the factors that influence the use of sunscreen by students of Ganesha University of Education. This study uses analytical observational method with cross sectional design, using interview based on prepared and standardized questionnaire. The technique used for sample selection was systematic random sampling in 5th semester students from 7 faculties with a total of 96 samples. The data were analyzed using chi square test including to assess the p value. The results showed a significant association between knowledge level and sunscreen usage (p = 0,003), and lifestyle (p = 0,033). It is expected that people would be able to increase their usage of sunscreen in their own arUltraviolet rays (UV) have various radiation waves, namely: UVA, UVB, UVC, infrared, and visible light with their respective effects on the skin. UVA radiation can penetrate the window glass and can react to chemicals of topical drugs and oral drugs which can cause a reaction called photoallergy and phototoxic reactions. Continuous radiation from UVA and UVB can cause degeneration of connective tissues in the skin such as sun-aging (photoaging), skin cancer (photocarcinogenesis), and immunosuppression on transplantation. Based on data from the Meteorology, Climatology and Geophysics Center, Buleleng Regency is one of the districts in Bali which has a high level of sun exposure intensity as compared with other districts. The purpose of this study were to determine the factors that influence the use of sunscreen by students of Ganesha University of Education. This study uses analytical observational method with cross sectional design, using interview based on prepared and standardized questionnaire. The technique used for sample selection was systematic random sampling in 5th semester students from 7 faculties with a total of 96 samples. The data were analyzed using chi square test including to assess the p value. The results showed a significant association between knowledge level and sunscreen usage (p = 0,003), and lifestyle (p = 0,033). It is expected that people would be able to increase their usage of sunscreen in their own areas through education regarding the function and danger of sunlight as well as maintaining a healthy lifestyle.