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Diatoms are unicellular photosynthetic microalgae, which dispersed in marine and freshwater environments. More than 200 diatom genus with around 100,000 species found in nature, each with different morphologies and dimensions. Their cell walls are composed of biosilica and exhibit species-specific nanoporous to microporous and macroporous patterning which is a promising renewable material for various applications, such as in catalysis, drugdelivery systems, sensors, and Biophotonics, due to the high surface area, mechanical resistance, unique optical features, and biocompatibility. In this study, biosilica of tropical marine diatom C. striata was used as a material for protein purification. The frustule of C. striata was washed with an acid solution and dried in oven. Remaining organic compounds were removed via calcination in a furnace. The biosilica was modified using 3-Mercaptopropylmethyl-dimethoxysilane (MPTS) and the obtained material was characterized using FTIR and SEM_EDX. The binding test capacity was conducted to evaluate the modified biosilica. The protein binding capacity of the modified biosilica was 14520 µg/mL.