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Malondialdehyde (MDA) is a metabolite resulting from lipid peroxidation by free radicals that can be formed when hydroxyl free radicals such as Reactive Oxygen Species (ROS) react with fatty acid components of the cell membrane so that a chain reaction is known as fat peroxidation. The fat peroxidation will break the chain of fatty acids into various toxic compounds and cause damage to the cell membrane. Thus MDA is an indicator of the presence of free radicals in the body. In this research, the Conjugated Linoleic Acid (CLA) antioxidant test was synthesized from castor oil in vivo against Wistar rats. Wistar rats were exposed to free radicals through cigarette smoke for 2 hours per day for 14 days. Mice were given an antioxidant intake of CLA with a concentration of 200, 400, 600,800,1000 mg / body weight every day with three repetitions. The same thing is done with intake of Ascorbic Acid (Vitamin C) and &