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Cockroaches are repulsive animals, cockroaches are also one of the vectors of disease that must be controlled. Some diseases which transmitted through cockroaches include dysentery, cholera, diarrhea, typhus, and etc. One way that can be done is to use a combination of Catebugu doses (eggshell and sugar powder) in killing / eradicating cockroaches. The study aims to determine the combination of Catebugu doses in eradicating cockroaches. This study was an experimental study using the Post-test only design, which is by combining Catebugu doses of cockroaches. Population Periplanata Sp) and samples were 150 cockroaches. The data that has been obtained will be processed manually presented in the form of a frequency distribution table and analyzed descriptively and statistical tests with Anova and List of Significant deferences (LSD). The study result of the combination of egg shells and powdered sugar in eradicating cockroaches, the fastest average time was 15 hours 33 seconds and the longest average time was 16 hours 7 minutes. Other combinations of natural ingredients are needed that can kill cockroaches in a relatively short time with a low level of danger.