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Background: Gynura procumbens (Asteraceae family) is a medicinal plant commonly used in Asian countries such as China, Thailand, Indonesia, Malaysia and Vietnam. G. procumbens contain of flavonoids and glycosides and have bacterial activity and anti-fungal activity such as Candida albicans and Aspergillus niger. Purpose: The purpose of this study was to obtain empirical data about the effect of using the G. procumbens leaves extract on reducing dandruff on the scalp. Methods: Scalp observation by examiners by using observation sheets and grating instruments assisted by a skin and hair analyzer. Reduction of scalp dandruff was the difference between the results of the initial test and the final test (after treatment). The sample was selected using a purposive sampling technique totaling 10 people and divided into two groups (experimental group and control group). Results: The results showed that the calculation of hypothesis testing after analyzing the data obtained a value of t-count (5.817) > t-table (1.86). This showed that there was an effect of using the continued use of leaf extract as a shampoo for reducing dandruff on the scalp. Conclusion: The use of G. procumbens leaves extract as shampoo can reduce dandruff.