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Background; Physiological disorders of the lungs can caused by decreasing oxygen supply which can be indicated by a decrease in oxygen saturation (SpO²) in patients with COPD. Oxygen saturation in patients with COPD can decreased by up to 85% which leads the patients to experience hypoxemia, cyanosis, decreased concentration to change in level of consciousness. Oxygen saturation of patients with COPD can be increased by applying non-pharmacological therapies such as breathing relaxation techniques by blowing balloons that can help expand the lungs so that they can supply the oxygen and release carbodioxide which is trapped in the lungs. Objective; This literature review aims to analyze the results of studies related to the effect of balloon blowing therapy on oxygen saturation in patients with COPD. Methods; The method of writing this journal used a literature review approaches from several databases, namely Google Scholar, PubMEd, EBSCO and NCBI. Totally, this literature review consists of 5 journals by using keywords for balloon blowing therapy, oxygen saturation and COPD. Results; The results of the study explained that there was a change in oxygen saturation in the patients with COPSD after applied a balloon blowing therapy. Conclusion; In this study, balloon blowing therapy has a significant effect on increasing oxygen saturation.