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Parkinsons disease (PD) the most common movement disorder and the second most common neurodegenerative disease after Alzheimers disease, is characterized primarily by the loss of dopaminergic neurons in the substantia nigra pars compacta leading to a dopamine deficit in the striatum. The standard therapy for Parkinson-s was levodopa (dopamine agonist) administration, but extended levodopa treatment often end up with dyskinesia. So, it-s needed the emerging alternative therapy for Parkinson-s. one of the most promising therapy is herbal remedies. Centella asiatica (CA) is one of popular herbs that has been used for many centuries for cure many disease such as bronchitis, memory improvement and neurotonic. In this study we explore the mechanism of CA to protect from Parkinson-s disease. We used SuperPred server to predict kinds of molecules that could bind to the certain protein. Four major active compound of CA (Asiaticoside, mdecassoside, madecassic acid and Asiatic acid) were docked using PatchDock and continuous using FireDock. One of interesting active compound was Asiatic acid, continued to further analyzed using Autodick Vina on PyRx 0.8, Molecular interaction (Ligand Scout V.2.0), Molecular visualization (chimera 1.8.1). Results showed that asiaticoside and madecassoside have strong anti-inflammatory activities due to their binding to the cyclooxygenase enzymes. While Asiatic acid and madecassic acid have specific binding to protein tyrosine phosphatase (PTP). FireDock analysis using 2F71 (protein tyrosine phosphatase 1b as receptor) and Asiatic acid as ligand (DSAsisticAcisCID119024.pdb) we found energy binding -6.62 kj/mol. Its known that if PTP 1b bound to certain molecule, the BDNF signalling will more strength. Because PTP 1b attenuate BDNF signaling. We can conclude that CA could protect Parkinson-s through the anti-inflammatory activities and strengthen the BDNF signaling.