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Background: Pneumonia is estimated as the third leading cause of death in Indonesia and the sixth cause of death worldwide. Although antibiotics are used to treat pneumonia, inappropriate use of antibiotics can lead to resistance and decrease its effectiveness. Objectives: This study was aimed to evaluate the use of antibiotics in patients with pneumonia at the inpatient pharmacy department of PKU Muhammadiyah General Hospital Bantul based on Guidelines from the Association of Indonesian Internal Medicine Specialists. Methods: This research was a descriptive non-experimental design. Data were collected retrospectively from 79 medical records of adult patients with pneumonia (January to December 2016) at the inpatient pharmacy department of PKU Muhammadiyah General Hospital Bantul. Data were analyzed descriptively and compared with the guidelines from the Association of Indonesian Internal Medicine Specialists 2010. Results: The results showed that there were 32 patients who filled the inclusion criteria. Seven out of 9 types of antibiotic use (83.34%) were appropriate according to the guidelines, namely azithromycin, cefotaxime, ceftazidime, ceftriaxone, ciprofloxacin, gentamicin, and levofloxacin, while 2 antibiotics (16,66%), cefixime and cefoperazone, were not listed on the guideline. Conclusion: In conclusion, antibiotic use in pneumonia is not entirely in accordance with the Association of Indonesian Internal Medicine Specialists guidelines.