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The objective this study is to analyze f2-isoprostane levels in the serum of a Wistar rat model of Alzheimers disease (AD) treated with Musa paradisiaca-Linn (MPL) ethanol extract or banana extract (BE). Twenty wistar rats were randomized into five groups: K0, without AD induction and no BE; K1, AD induction, no BE; K2, AD induction + BE 250 mg/kg body weight (BW); K3, AD induction + BE 500 mg/kg; and K4, AD induction + BE 1000 mg/kg. Alzheimer-s disease (AD) induction was performed by Aβ1-42 (0.2 ug) injection at the intracerebroventricullary area. F2-isoprostane level measurements were performed by Elisa kit. Paired t-test analysis showed no significant differences of f2-isoprostane serum level before Aβ induction among 5 groups (p > 0.05). At 6 weeks post- Aβ induction, there was significant increased f2-isoprostane in all groups except K0 (p < 0.05). Notably, after 3 weeks of BE administration, f2-isoprostane serum level was significantly decreased in all BE-treated groups; in the K1 placebo group, f2-isoprostane level increased. The maximum decreased f2-isoprostane level was in group K4 (-BE 1000 mg/kg BW), and minimum was in group K2 (BE 250 mg/kg BW). The results revealed that the ethanol extract of MPL fruit could decrease f2-isoprostane level in AD rat serum.