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Background: Nurses who have good spiritual intelligence are used to build awareness on the basis of worship and the help of human needs. Spirituality can help patients to understand the way of life and find their confidence. Therefore, they can be able to and find hope, inner harmony and composure. Purpose: The purpose of this study was to determine the relationship between nurses spiritual intelligence with fulfilling patients spiritual needs in the hospital ward PKU Muhammadiyah Gamping. Method: This research used quantitative method with cross sectional research design. The sample in the study were 91 nurses who worked and served in the wards of PKU Muhammadiyah Gamping Hospital and were willing to fill out the questionnaire which is determined by simple random sampling method. Result: Most of the nurses at PKU Muhammadiyah Gamping have spiritual intelligence in good category (82.4%) and fulfilling patients spiritual needs with good category (62.6%). The result of statistical analysis showed that there is relation between nurses spiritual intelligence and fulfilling patients spiritual needs with value p = 0.002 (<0.05) shows there is relation between spiritual intelligence with spiritual fulfillment. Conclusion: The better the spiritual intelligence a nurse has, the better the act of spiritual care that will be done to meet the spiritual needs of the patient.