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This research aimed to develop the chemistry students- soft skills students through acid-base learning by integrating Think Pair Square (TPSq) in socio critical and problem-oriented approach. The study involved 36 secondaty school students in year-11. The qualitative research methodology with interview, observation, and reflective journal were employed to understand the process and engage the participants. The issues of 1000mg vitamin C, “kangen water”, and infused water in relation to acid-base concept water were used to encourage students- critical thinking in solve the problems. The results showed that students engaged and motivated in meaningful chemistry learning experiences, meanwhile the teacher were challenged in the role as facilitator. The students- soft skills of collaboration and communication skills, critical and creative thinking skills were stimulated within the process. The students have learnt to reflect on their own values during debate in solving the problems. Finally, the learning experiences have challenges both students and teacher in reflecting on their roles to create challenging academic environment.