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Brain injury caused by physical trauma in our TBI (trauma brain injury) rat model, have been approved to recover after administered by total catechins derived from green tea. The improvement have been detected in the increase of the neurological severity score (NSS). While in the molecular level, the improvement could be detected through the decrease of TNF alpha, caspase 8, caspase 3, NFKappa B p65 and also the increase of the BDNF and ratio BCl2/Bax. Hyperglycemia could damage the brain that can be seen in our memory spatial rat model. The administered of the total anthocyanin derived from sweet purple potatoes Ipomoea batatas L. kultivar Gunung Kawi, was used to these animals to improve the memory spatial of the rat. It can be determined through the molecular level, such as the decrease of the MDA, Caspase 3, TNF alpha and also the decrease of the travel time Morris water maze However there is still problems to decide the exact rationale doses of these two natural anti-oxidant. Therefore, it is a deemed to continue to elaborate the doses.