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The purpose of this research is to know how to influence the progress of information and communication technology and entrepreneurship education in business interest. The technology progress that is so fast can make it easy for everyone to get information, including to create busness opportunities. Supported with the entrepreneurship education will create interest and business opportunities that are becoming increasingly large. This research using descriptive analysis method to obtain information needed in the research process. The results of this research indicate that technological progress and entrepreneurship education have a significant effect on the busisess interests for students. The results are obtained because people who have studied entrepreneurship and also interested in the development of information and communication technology will have a greater interest to do business. The application of information technology is very useful in teaching entrepreneurship, for example as a marketing medium, and so on. Therefore, ICT and entrepreneurship are two things that are interrelated in their implementation From the results of the research can be concluded that technological progress and entrepreneurship education can effect a person-s interest to do business and have a strong desire to create jobs in the future.