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Kebiul seeds (Caesalpinia bonduc) are seeds from the Kebiul plant that are widely used by the serawai tribe in Bengkulu Indonesian as malaria medicine. The purpose of this study was to scientifically prove the efficacy of Kebiul seeds as an anti-malaria medicine preclinically in mice by measuring percent (%) chemosuppresion of crude extract of Kebiul seeds. Twenty-five mice were divided into 5 groups, K-, K +, P1, P2 and P3 each group were infected with Palsmodium berghei, three days after infection, the number of parasitemia that infected eritrocytes of mice was calculated, if the number of parasites had reached 20-30%, then mice were treated orally for 3 days according to their group. Group (K-) treated with olive oil, group (K +) with chloroquine, and groups P1, P2 and P3 were treated with crude extract of Kebiul seeds at a dose of 0.028 g / kgbw; 0.056 g / kgbw and 0.084g / kgbw. The average number of parasitemia developments is calculated from the first day of treatment to up to 7 days. The average percent (%) chemosuppresion in the administration of crude extract Kebiul seeds at a dose of 0.028 g / kgbw was 51.21% higher than the administration of chloroquine (50.77%). Based on this result, Kebiul seed extract at a dose of 0.028 g / kgbw can be developed as a new traditional medicine as a substitute for anti-malaria medicine chloroquine, because it has been reported in several areas including Bengkulu that malaria is resistant to chloroquine.