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Biodiesel is one of the alternative energy that is environmentally friendly and can be renewed. In general, biodiesel is made through a transesterification reaction between oil and ethanol with the help of a base catalyst. However, one obstacle to the commercialization of biodiesel is the high cost of production. Cheap raw materials (rice bran oil) contain high free fatty acids (up to 60%) therefore the transesterification reaction is only possible using an acid catalyst and the rate of the transesterification reaction is slower under conditions using an acid catalyst. In addition to further reducing the cost of production is by carrying out a transesterification reaction under mild reaction conditions, namely at room temperature and atmospheric pressure. Therefore, this research will be assisted by high shear mixing so microemulsion formed to minimizing mass transfer resistance and reaction can occur. The effect of dispersion speed, catalyst amount, reaction time and molar ratio between ethanol and rice bran oil were investigated so the cost of production can be reduced. In addition, the energy consumption needed for biodiesel production from rice bran oil assisted by high shear mixing is lower than conventional or subcritical / supercritical methods.