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UTILIZATION OF MICROWAVES FREQUENCY FOR IDENTIFICATION OF OVARIUM CANCER TISSUE IN INTRAOPERATIVE CONSULTATION PROCESS
Faris Dinulhaq1), Rizki Putra Prastio2), Tati Latifah R. Mengko2), Ali Budi Harsono3), Bethy S. Hernowo3), Marselina Irasonia Tan1)

1) School of Life Sciences and Technology-Institut Teknologi Bandung
2) School of Electrical Engineering and Informatics – Institut Teknologi Bandung
3) Hasan Sadikin Hospital & Medical School-Padjadjaran University


Abstract

Cancer is a disease caused by cell proliferation abnormalities. One of the methods that can be used to overcome this disease is by removing the cancerous tissue. Identification of cancer tissue in the operation stage (intraoperative consultation) is an important stage for the surgeon to determine the next action. Until now, tissue identification in intraoperative consultation is still done manually using cryosection methods. The cryosection method is reported to have fairly good accuracy in the identification of cancerous tissue. However, the accuracy of this method is very dependent on the experience and skill of the doctors, so this method is very vulnerable to human error. To overcome this problem, a standardized identification method for a cancer tissue in intraoperative consultation is needed to reduce the human error. The development of cancer identification methods by using tissue permittivity at microwave frequencies in recent years has shown quite promising results. This is because the measurement of tissue permittivity using microwave frequencies can be performed several times without damaging the samples. In addition, several studies on several types of cancer showed differences in tissue permittivity between cancerous and normal tissue. Until now there are no studies that report the application of this method, especially for intraoperative consultation for ovarian cancer. To answer the problem, this study aims to create and test the tool that been made that can distinguish cancerous and normal tissue based on the tissue permittivity value using microwaves frequencies. Besides being able to minimize human error, the device is designed to be portable and able to provide diagnostic results faster than the cryosection method. The initial stage of this research is the production of the tools. The device that has been made is then tested for the ability to differentiate tissue based on water content parameters and tissue type before measuring cancer samples. Measurements are made every 0,002 GHz in the microwave frequency ranging from 8,2 to 12,4 GHz or around 2000 measurement points using TE10 measurement method. The measurement results then processed using the TPS (transmission phase shift) method to determine the permittivity value. The next stage is the measurement of ovarian tissue samples (n=12) obtained from Hasan Sadikin Hospital (RSHS) Bandung. The tissue obtained was identified by RSHS medical doctor diagnosis. Fresh sample from the surgery is then measured in less than 2 hours. The permittivity values of each tissue are then compared and their significance is tested using statistical analysis. The tool that designed was successfully made in a relatively smaller dimension (6,28 x 23,5 x 2,11 cm) that made this tool portable. Measurement of tissue samples using this tool is done within ± 5 minutes from sample preparation until the results came out, so this tool can analyze tissue samples faster than the cryosection method which ge

Keywords: microwaves, permittivity, ovarian cancer

Topic: Biomedical, Robotic and ICT engineering

Link: https://ifory.id/abstract/yGcMhjbaL7uU

Conference: The 1st Bandung Applied Biomedical and Technology in Health Conference (BABTECH 2019)

Plain Format | Corresponding Author (Marselina Irasonia Tan)

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