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The world is entering era of the Industrial Revolution 4.0 which information technology has become the basis of human life. To deal with this era, need to be prepared for more innovative learning system and in accordance with technological advances. Therefore, STEM-based learning can be a solution in the face of such challenges.This study aims to develop a practical method based on STEM in the manufacture of toothpaste from the chicken in the eggshell colloid material. Utilization of eggshell been due to potential high calcium content and change the eggshell is usually wasted as waste into new products that can be used. The research methods used RnD is comprised ofthe planning stagesdo is design the practicum in order to STEM-based produce worksheets and in the development process validation test applied by experts. Participants are students of class XI, teacher and validators Data collected with the validation sheet techniques, questionnaires, and observation activities of teachers and students.This research resulted in the design of a viable practical methods such as lesson plans and worksheetspracticum, so that it can be concluded that the design method STEM-based practicum in the manufacture of toothpaste from chicken eggshells can be applied in learning colloid material.