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Abstract Objective: To analyze the difference of compressive strength between nanofilled composite resin and nanofilled composite resin reinforced with braided polyethylene fiber. Methods: Samples were made on pipette molds that are 10 mm in diameter and 10 mm in height. The first group contains only nanofilled composite resin. The second group contains nanofilled composite resin reinforced with braided polyethylene fiber. The samples were irradiated on a 2 mm layer for 20 seconds. The whole sample hardened, then incubated at 37oC for 1x24 hours. The samples then tested their compressive strength by using a universal testing machine. Statistical used independent sample t-test. Result: Compressive strength of nanofilled composite resin is 122.571 MPa and nanofilled composite resin reinforced with braided polyethylene fiber is 141.186 MPa, and based on statistical test determined p = 0.009 < p = 0.01. Conclusion: There was a difference of compressive strength between nanofilled composite resin and nanofilled composite resin reinforced with braided polyethylene fiber