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Abstract Objective: To evaluate the prevalence of anemia in pregnancy and determine the relationship between maternal anemia during pregnancy and low birth weight, babies. Method: This study was a cross-sectional design which was conducted at Siti Khadijah 1 Tertiary Hospital from January 2017 to October 2018. The total sample of the study was 6876 samples. Result: Anemia prevalence was 46.6%. Mothers with anemia were more likely to give birth to babies with low birth weight compared to mothers who were not anemic, which is 373 respondents (11.7%) versus 265 respondents (7.2%). Respondents with severe anemia gave birth to more babies with low birth weight than babies with normal birth weight, which is 49 people (92.5%) versus 4 (7.5%) (p=0.000, p <0.05). Conclusion: There was a significant association between maternal hemoglobin and birth weight.