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HPMC inhibit mannitol re-crystallization in air-dried liposome formulations
RADITYA WEKA NUGRAHENI1,2, HELMY YUSUF1, DWI SETYAWAN1

1Department of Pharmaceutics, Faculty of Pharmacy, Universitas Airlangga
2Department of Pharmacy, Faculty of Health Sciences, Universitas Muhammadiyah Malang
Jl. Dharmawangsa Dalam 60286, Surabaya, Indonesia


Abstract

This study evaluated the role of HPMC to inhibit mannitol crystallization in air-dried liposome formulation. HPMC has been used in solid dispersion to prevent crystallization of several drugs. The mannitol and HPMC were included in the developed formulations with 4 different weight ratios and air-dried at 40ºC for 120 h. Liposome was composed of SPC:DDA:Chol (9:3:1 in molar ratio). XRD data showed crystalline-forming properties as function of mannitol and HPMC ratio. The formula with highest mannitol:HPMC ratio (4:1) showed most obvious crystallinity, while the lowest ratio (2:3) indicated amorphous solid. DTA analysis found that the later formula showed broad endothermic peak at 150-170ºC, indicating amorphous solid. SEM data supported these results where no crystalline structure was observed in the later formulation. The rest (2:1 and 4:3) formula showed partially amorphous and partially crystalline. From XRD and DTA data, there are two polymorphs of mannitol observed in the formulations, delta and beta-mannitol. From the findings, it can be concluded that incorporation of HPMC as dispersion matrix potentially inhibits crystal formation in the developed formulation.

Keywords: Liposome, Air-Drying, Mannitol, HPMC, Crystallizations

Topic: Pharmaceutical Science

Link: https://ifory.id/abstract/3YeGmZ4wxzAD

Conference: The 2nd Health Science International Conference (HSIC 2019)

Plain Format | Corresponding Author (Raditya Weka Nugraheni)

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