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Cashew (Anacardium occidentale L.) apple are rich in nutritional value, especially vitamine C and bioactive compounds such as tannins that are very beneficial to support health. This research aims to find out the effects of cashew apple juice of lipid profile and its potential as an anti-Hypercholesterol agent. In this study used experimental animals in the form of male Whistar Rats Type (Rattus norvegicus) as much as 21 rats are divided into 3 groups and each group consists of 7 rats were fed with AIN 76 diet for 28 days, given the treatment of cashew apple fruit juice 2 ml, 2 times a day by were force-fed and as control treatment is given only drinking aquabides. The results showed that cashew apple juice was influential for the lipid profile of the whistar rats experiment, potentially as an anti-Hypercholesterol agent by lowering total cholesterol levels (6.37-7.16)%, Trigeliserida (9,71-10,76)% LDL-Cholesterol (11,19-13,37)% and increased cholesterol levels of HDL (6,10-6.46)%.