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Abstract Objective: This systematic review was aimed to understand the management of endodontic-periodontic lesion. Methods: Pubmed and Wiley online searches were conducted to identify articles published in dental journals until April 2018. Manual searches of published full-text articles and related reviews were performed afterwards. Result: A total 16 studies were selected for inclusion, with 22 patients as subjects. All studies showed the decreased probing depth (PD) after treatment or healing of the lesion. All studies included were case report with treatment using root canal treatment (RCT) alone or RCT combination with bone graft or RCT with platelet rich fibrin (PRF). Conclusion: Treatment using root canal treatment (RCT) combination with bone graft was mostly used than the other treatment option in endo-perio lesion.