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This research aims to prove empirically whether applying maqashid sharia and the maximal role of the sariah supervisory board on sharia operations can lead to positive profit growth in Islamic banks in Indonesia. The performance of maqashid sharia is measured using the Maqashid Shariah Index (MSI) while the sharia supervisory board is measured using the number of sharia supervisory boards. This study uses a purposive sampling method, in order to obtain eleven Islamic banks registered. Hypothesis testing using multiple linear regression. The results of this research found that applying of maqashid sharia and the maximal role of the sharia supervisory board could lead to positive profit growth in Islamic banking in Indonesia.