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Staphylococcus aureus is a bacterial pathogen that causes bacteremia and infections in several organs of the body as well as infections that are transmitted through medical equipment. In the case of bacterial infections, the data shows an increase in the amount of resistance and changes in the spectrum of disease. This study aims to evaluate the activity of the ethyl hexane fraction of landep leaves ethanol extract against Staphylococcus aureus bacteria. The method used is an experimental method where the ethyl hexane fraction of landep leaves ethanol extract was tested on 5 groups of mice at a dose of 0.3 mg /kg; 0.6 mg /kg; 1.2 mg /kg; 2.4 mg /kg and 4.8 mg /kg. We are using NaCl as a negative control group and Amoxicillin 500 mg/kg as positive control group. Intravenous fluids from mice that have been treated are cultured on agar media and counted bacterial colonies. The results showed that the fraction of landep leaves gave an antibacterial effect at a dose of 2.4 mg / kg BW and 4.8 mg / kg BW but it was not significant compared to Amoxicillin administration