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ABSTRACT The focus of the research is to explain the types and diversity of creative industry businesses, the creative economy, interacting with each other in forming their business networks, creating business agglomeration. Analyze the linkages and business networks that shape agglomeration and encourage economic growth. The research method is the panel data method with five destination regions during the 2015-2017 period. The estimation method uses Pooled least square (PLS) and fixed effect method (FEM) through testing the model with a likelihood ratio. The results showed that the most dominant form of creative industry business in West Sumatra was the super creative business group, most of whom were Educator Workers, Librarians, Trainers and researchers, arts, sports and entertainment media workers who accounted for 74% of the total creative industry workforce. there is. Creative professional groups consisting of technical workers, salesman nurses more or less reach 26%. The largest is spread in the city of Padang and Bukittinggi. Changes in the concentration of industrial clusters have a positive impact on regional innovation and economic growth, an increase in the intensity of the use of R&D has a positive impact on regions with concentrations of industrial clusters, a negative impact on regions that do not yet have a creative industry cluster. The more agglomeration of industrial business is created due to the creative industry business cluster, the more positive it is on economic growth. Conversely, if industrial clusters are not yet formed, it will have a negative impact on regional innovation and regional economic growth