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Background: Jobs related to the nursing profession will always be stressful, traumatic or difficult because of the difficulties inherent in nursing work. Some researchers have documented resilience among nurses and have conceptualized nurses as resilient populations of health services, but there is still a dearth of qualitative studies that hear personal narratives about why nurses remain and develop in stressful workplaces in the context of nurses working in remote areas. Objectives : The objectives of this study were to explore, understand, and ultimately illustrate the lived experiences and meaning of nurses work resilience in remote health centers areas, eastern Indonesia. Methodology: This qualitative study was conducted by qualitative content analysis approach. Six nurses selected for participation using purposive sampling technique and determined based on inclusion criteria. Data were collected through semistructured interviews in depth until saturation was reached. The interviews were transcribed verbatim, and the qualitative content was used to analyze the data. Results: The researcher identified two themes: tough nurses; they will depend on social support from colleagues, family, or even the work environment to continue to assume responsibility and continue to develop and move forward even in difficult situations. They will tend to think positively, use humor to have fun and laugh and depend on spiritual beliefs that allow them to continue to adapt to the difficulties during their duty. Conclusion: This study explains the superiority of resilience shown by nurses working in remote health centers in eastern Indonesia