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The purpose of the study was to analyze mens knowledge about vasectomy and respondent-s characteristics that influenced the level of knowledge. The study applied quantitative descriptive research with a cross-sectional approach. The populations in the study were all men with several criteria such as being married, actively having sex, and living in Meguwo Banguntapan Bantul. The data collection tool used a questionnaire. Data analysis employed univariate analysis. The results of the knowledge level of respondents were divided into 3 categories 29 (48.4%) high, 26 (43.3%) moderate, 5 (8.3%) low. A total of 98.3% of respondents knew the definition of vasectomy; 84.2% knew how vasectomy worked, 41.7% effectiveness, 60% profit, 56.7% loss, and 74.8% vasectomy requirements. Although many respondents had sufficient knowledge about vasectomy, none of the respondents were interested in doing a vasectomy.