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Introduction: Mental conditions in children and adolescents today are very alarming. This condition is characterized by an increasing number of children and adolescents who experience psychosocial problems such as depression, substance abuse, crime and others. The impact of depression on adolescents can arise, among others, performing various actions such as non-suicidal self-injury (NSSI), attempted suicide, even to death from suicide. Biopsychosocial factors in NSSI patients are very important to be traced because they play a role in the etiology, course of the disease, management and prognosis of the patient. Case report: A 13-year-old teenage girl with a chief complaint of self-injury a year ago. The patient injures himself with a cutter or razor on his arm which is getting done more and more frequently so that there are more injuries to the patients arms and thighs. But apparently many friends of patients at school who do the same thing. Biopsychosocial approaches are applied to patients and their families, including the provision of psychopharmacotherapy and psychotherapy drugs to patients so that children can be independent and adapt to the environment. Family education and therapy is carried out so that the family can support the therapy process. Conclusion: The biopsychosocial factor approach to NSSI is satisfactory.