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Objective: This study aimed to determine the quality of life experienced by prolanis participants using the WHOQOL-BREF Indonesian version. Prolanis is a program designed by Social Health Insurance Administration that is integrated with the management model of chronic diseases due to the high prevalence cases of chronic disease in the community. Methods: This research was analytic observational with a cross-sectional design by exhaustive sampling technique. These instruments use WHOQOL-BREF and prolanis guidance. The samples was 86 patient which divided into two locations, that was 37 respondents from Tamamaung Primary Health Care (Puskesmas) and 49 respondents from Dahlia Puskesmas. Data collected were analyzed by chi square statistical test to find out the association of the four domains quality of life between activeness participations and rest patterns. Results: Based on the analysis, the results of the general quality of life of prolanis participants in both Puskemas was not different (p-value = 0.276) While the health satisfaction variable has a difference with p-value = 0,000. Conclusion: Most of the prolanis participants have a high QoL scores in some facets of every domain in the WHOQOL-BREF questionnaire but collectively results do not show an association between 4 domain quality of life to activeness participants and rest patterns.