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The infection is a condition the entry of microorganisms into the body multiply and cause disease. One of the causes of the infection is bacteria, antibacterial gift is one of the elect in dealing with infectious diseases. One of antibacterial from herbal plants, namely cananga flowers with the content of the active compounds that are able to act as an anti-microbial. The methods used to extract compounds rates cananga is extraction. Extraction techniques organic compounds used in this research is macerasion which is used polar methanol solvent. And in order to know the methanol extract compounds gaint the researcher used GCMS analysis. Then tested the sensitivity using methanol extract agains Gram positive and gram negative bacteria. So it is know the resistor power of methanol extract from cananga flowers (Canangium odoratum) against the growth of Gram positive and gram negative bacteria. This research uses observational analytical design using purposive sampling techniques. The results obtained are methanol extract in cananga flowers (Canangium odoratum) and the its resistor power against Gram Positive and gram negative bacteria as a role of antibacterical. The highest compounds in the extract is alpha-Bergamotene with area 22,65 % and the lowest compounds is Alpha, -Copaene and 9.12-Octadecadienoic acid (Z,Z)-, methyl Esther (CAS) Methyl linoleate with area 0.51 %. In addition, the extract is capable to inhibit the growth of Gram positive bacteria (Stapyloccocus aureus) with diameter of the 15 mm. Methanol extract of cananga flowers can only inhibit positive gram bacteria with diameter of the 15 mm.