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Diabetes mellitus is a metabolic disease characterized by chronic hyperglycemia due to abnormal insulin secretion, insulin action or both. Breadfruit has been used in traditional medicine for diabetes mellitus. This study aims to see the effect of giving ethanol breadfruit leaf extract to pancreatic damage induced by alloxan-nicotinamide. Rats were induced with alloxan-nicotinamide and grouped into 4 groups, namely group I (normal) without treatment, group II (positive) given metformin 100 mg/kg body weight (BW), group III (negative) given Na CMC, group IV given breadfruit leaves extract 100 mg/kg BW, group V given breadfruit leaves extract 400 mg/kg BW. Treatment given for 14 days and histopathological examination of the pancreas. The results showed that group I pancreatic histopathology was not damaged, Group II suffered damage of 25% -75%, Group III with 25% damage, and group IV showed 50% and group V showed pancreatic damage from 0-25%. Breadfruit leaves extract 400 mg/kg BW has better activity to protect the pancreas and reduced the effect of pancreatic damage in rats.