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This research aims to determine the improvement of science process skills of students using the Scientific Inquiry model with algodoo media and adversity quotient. This type of research is quasi experimental research using two group pretest-posttest design. The population in the research was all students of class X Muhammadiyah 2 High School Medan. The sample in this research was taken by cluster random sampling technique, that is as much as 2 classes. X-MIA 1 class as an experimental class taught using the scientifiq inquiry model with algodoo media consisting of 35 students, X-MIA 2 class as a control class taught with conventional learning consisting of 34 students. The instrument of this research uses essay test of science process skills and adversity quotient with a list of questionnaire statements. Data were analyzed using two ways anava. The results showed that the improvement of science process skills of students taught using the scientific inquiry model with algodoo media was better than the science process skills of students with conventional learning, improved science process skills that had higher adversity quotient type climbers better than students who have a lower adversity quotient type of campers, there is an interaction between the scientific inquiry model and algodoo media and adversity quotient students in improving students science process skills.