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Smoking habit can lead to oral diseases. Moreover, not many people are aware of the relationship of smoking with potential oral diseases. Micronuclei (MN) count is a promising indicator for the cytotoxic effects of smoking. Our study was aimed at establishing a correlation between the MN counts and oral hygiene index among smoking habits. A total of 62 subjects were examined with smoking habit. Oral mucosal cells were collected from both sides of cheeks, slides were prepared and examined for cells with micronuclei where the presence of micronuclei was assessed under Χ100 magnification. Oral hygiene index is measured by simple instrument screening to assess debris and calculus index of teeth. The results shown that there was no statistically significant correlation between MN and OHI of smoking habits. The null hypothesis that the correlation is zero and not linear is accepted (P 0.61 is greater than the significance determined alpha 0.05) with the correlation value -0.07. There was no correlation between MN and OHI of the smoking, but the genotoxic effects of smoking cause chromosomal damage in the epithelial cells of the oral mucosa and are reflected in the occurrence of micronuclei and the poor of oral hygiene index of smoking.