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EFFECTS OF EPINEPHRINE ADMINISTRATION ON GONADOTROPIN HORMONE OF FEMALE JAPANESE STRAIN MICE (MUS MUSCULUS)
Debby Sinthania, Linda Marni

Universitas Negeri Padang


Abstract

Physical, chemical and psychological stressors can affect GnRH pulsatile frequency and amplitude. This is important for FSH and LH secretion. Moreover, stressors can also activate the sympathetic nervous system (norepinephrine release) and adrenal medulla (epinephrine release). Catecholamines increase (epinephrine and norepinephrine) can increase GnRH pulse. The excessive pulse increase can reduce and stop FSH and LH secretion. Epinephrine is a chemical stressor, so, this research aims to prove the effects of epinephrine administration on FSH and LH level. It is an experimental laboratory research using post test only control group design. The examined variables were FSH and LH level. This study used 24 female mice (Mus musculus) consisted of 6 groups; 1 control group and 5 treatment groups based on the epinephrine administration of 0.001 mg/ml, 0.002 mg/ml, 0.003 mg/ml, 0.004 mg/ml, and 0.005 mg/ml respectively, given every day for 20 days startedfrom the beginning of proestrus cycle. Then the result was analyzed using One Way ANOVA method and followed by Multiple Comparison Bonferroni test. The result indicates that the dosagelevel in epinephrine administration indicates a significant difference (p <0.05) on FSH and LH level of 0.001 mg/ml and 0.002 mg/ml, 0.003 mg/ml, 0.004 mg/ml, 0.005 mg/ml by control. From the result, it can be concluded that chemical stressors (epinephrine) can reduce FSH and LH level. It is recommended to conduct a further research with measurement of Estrogen and Progesterone level and Catecholamine level.

Keywords: Epinefrin, FSH, LH

Topic: Medical and Surgical

Link: https://ifory.id/abstract/9pM7uVAaYUbz

Conference: The 2nd Health Science International Conference (HSIC 2019)

Plain Format | Corresponding Author (Aulia Asman)

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