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Abstract Objective: This study aimed to determine the effectiveness of soursop leaf extract (Annona muricata L) on IL-10 levels in mammary sprague dawley mice induced by Staphylococcus aureus bacteria. Method: This study used the true experimental research type with the design of the post-test Only Control Group Design. The sample of this study was Sprague Dawley female rats with a weight of 200-250 grams as many as 20 animals which were divided into 4 groups (5 each), namely the negative control group that was not given treatment, the group given cefadroxil antibiotics 45 mg / kg BW / 12 hours, the group given soursop leaf extract 100 mg / kg BB and soursop leaf extract group combination of cefadroxil antibiotics. All groups were induced by Staphylococcus aureus 2 x 107 CFU / ml then given treatment for 5 days. Examination of IL-10 levels using the ELISA method and data were analyzed using one-way ANOVA. Results: The results showed that there was a difference with increasing levels of IL-10 cytokines in the three treatment groups compared to the negative control group (p = 0.002). This shows that the soursop leaf extract can suppress inflammation of the IL-10 cytokine levels in female mammals. Thus soursop leaf extract can be used as a complementary therapy for inflammation.