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Introduction : There are almost one billion young people aged between 10 and 24 years who live in Asia. These young people live in diverse socio-cultural and economic contexts, but there are important challenges and opportunities related to their sexual and reproductive health. Knowledge about reproductive health should already be possessed by adolescents, through information media it is very easy to get it. But with the vast amount of knowledge possessed by teenagers, it has not been able to foster a sense of belonging to their reproductive health status. Methods : This research was conducted with an observational research design through a cross sectional study approach. The population in this study were high school students in East Java - Indonesia. The sampling technique used was purposive sampling technique. Obtained a sample of 221 respondents. Result : The value of the results of multiple logistic regression tests conducted simultaneously on the three variables obtained significant results are as follows, X1 (0,000), X2 (0.122) and X3 (0.009). From these results it can be said that when tested simultaneously (simultaneously) X2 is said to be insignificant because of the sig value. X2> 0.005. So to determine which factors are most influential, just compare the odds ratio (OR) values of X1 and X3, which are 0.069 and 0.218. Where from the value of the two variables that have the greatest odds ratio is on biological and psychological factors. Conclusions : Various factors that become variables on adolescent awareness about reproductive health are social, economic and demographic factors, cultural and environmental factors as well as biological and psychological factors affecting the level of adolescent awareness of their health in terms of reproduction. Of the three components of the factors mentioned above, biological and psychological factors have the greatest influence.