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Objective : This study aimed to analyze the effectiveness of soursop leaf extract on IL-6 levels in mammals of Sprague Dawley mice induced by Staphylococcus aureus . Method: This study is a True Experiment which is a laboratory experiment, with the design of the Post-test Only Control Design Group . The study was divided into four treatment groups consisting of five rats induced by S. aureus 2 x 107 CFU / ml , 1 x 24 hours. Group I (negative control) who were only given Na. CMC 0.5%, Group II (Positive Control) with cefadroxil antibiotics 45 mg / kgBB, group III with soursop leaf extract 100 mg / KgBB, and group IV administering ethanol extract of soursop leaves in combination with cefadroxil antibiotics. Each group was treated twice in a day (12 hours ) for 5 days. Levels of IL-6 were measured on day 3 and day 6 after induction of S. aureus, tested by ELISA technique and analyzed by One Way Anova test and Paired Samples T test Results : N values of IL-6 levels in group III of 7 , 50 ± 1.74 pg/ml on day 3, and 4.51 ± 1.47 pg/ml on day 6. The results showed that there were differences in IL-6 levels in the group given the soursop leaf ethanol extract (ρ = 0.037 <0.05) . Conclusion: Ethanol extract of soursop leaves can be used as a complementary therapy for mastitis caused by the Staphylococcus aureus bacteria