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This study aims to obtain an integrated Science Practicum handbook integrated guided inquiry models based on students science process skills by adjusting KIT to practicum activities in the development book. The sample in this research were 2 integrated science practicum guidebooks with different publishers for class VII SMP / MTS Semester I. The practicum guides that have been developed are validated by 2 expert lecturers of chemical and biology study programs in Postgraduate State University of Medan and 4 teachers in the field of Natural Sciences, and tested it to 2 classes. The sample selection uses a purposive sampling technique. The instruments in this study were: 1) the guide feasibility test sheet based on BSNP; 2) KIT feasibility test sheet based on the Ministry of Education and Culture 3) Student learning outcomes test; 4) observation sheet of students science process skills; 5) student response questionnaire. The research data were then analyzed using SPPS 20 for window through tests of normality, homogeneity, and t test. The results of this study indicate (1) the results of the analysis of the feasibility level of integrated science practicum guides used in schools from two different publishers have an average value of 2.85 with a feasible category, but there are several components of the guide that need to be developed. (2) the results of the developed Ministry of Education and Culture KIT questionnaire have a very feasible category, so it is feasible to use in integrated science learning (3) the results of students science process skills by getting a percentage of 82.1% with a good category. (4) Student cognitive learning outcomes show there are differences in student learning outcomes using the guide and KIT integrated science practicum integrated science model guided inquiry based on science process skills that is (tcount> ttable, 4.801> 1.672). (5) The students responses to the guide and KIT practicum developed showed a positive response 96.77% with a very good category.