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Background: Intravenous (IV) line infusion therapy is one of the actions most often given to patients undergoing health care. The ability to insert IV line is the competence and responsibility of a nurse. Installation of IV line is very important so that it must be done correctly in accordance with the standard operating procedures that are applied to avoid complications such as phlebitis or inflammation of the tunic intima vein. Objective: The purpose of this study was to determine the causes of phlebitis in infusion in the inpatient room at a Western Indonesian Private Hospital. Method: The design of this study is descriptive quantitative research with documentation study data collection methods (check list). This sampling technique uses a purposive sampling technique to 50 respondents who are being treated at the hospital. The instrument for measuring this research is a documentary study sheet using Visual Infusion Phlebitis (VIP) Score from Andrew Jackson. Results: The results of this study is 32 people (64%) respondents who experienced phlebitis or PIVAS scores more than or equal to one (≥ 1) from 50 people who IV line was removed in the hospital). The three main factors causing phlebitis in this study were Intrinsic factors (gender, age, comorbidities) of 82%, chemical factors (type and speed of fluid) of 52%, and mechanical factors (catheter size, location and length of insertion) of 98% . Conclusion: The conclusion of this study is that there are main factors causing phlebitis in patients in a Western Indonesian Private Hospital, namely intrinsic factors, chemical factors, and mechanical factors with the highest frequency causes of phlebitis is a mechanical factor (98%) and intrinsic factor (82%). suggestion n) for further research is that this study can be used as a reference to redevelop the analysis of more specific causes of phlebitis